	   SnapGene      .MacgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtATCGGTtaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttatcgatactagtattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtTtatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagattctagagctagcCTGATACGAACTCGgaattcGCCACCatgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccggcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcagttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtggtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaagaccatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcctttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagcagtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaatttacaggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggagagcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttccagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctggggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctccgggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgcacaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgcaaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaaccccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtggtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaagacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaataggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaaaactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactccttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaaatcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgcctttgagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtcgtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagatgtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactgtttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaaggccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagcccagggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaaccttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccacccagagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatccagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatgggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgccatccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatgggcctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtggccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcggaggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaaccaagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctccggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaattcccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctcgatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatctgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggactatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcagatcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagccaggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaactgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtggatggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctacggggtgactgtttgggagttgatgacctttggatccaagccatatgacggaatccctgccagcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtaccatcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaagttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtcattcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgccctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacagcagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgcaaccagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatcaaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggacagcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaaggcccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagcagagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaacactgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaaggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaagccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtcgcgccacaaagcagtgaatttattggagcatgaggatccCTGCGATATCCAGCgcggccgcGaaggatctgcgatcgctccggtgcccgtcagtgggcagagcgcacatcgcccacagtccccgagaagttggggggaggggtcggcaattgaacgggtgcctagagaaggtggcgcggggtaaactgggaaagtgatgtcgtgtactggctccgcctttttcccgagggtgggggagaaccgtatataagtgcagtagtcgccgtgaacgttctttttcgcaacgggtttgccgccagaacacagctgaagcttcgaggggctcgcatctctccttcacgcgcccgccgccctacctgaggccgccatccacgccggttgagtcgcgttctgccgcctcccgcctgtggtgcctcctgaactgcgtccgccgtctaggtaagtttaaagctcaggtcgagaccgggcctttgtccggcgctcccttggagcctacctagactcagccggctctccacgctttgcctgaccctgcttgctcaactctacgtctttgtttcgttttctgttctgcgccgttacagatccaagctgtgaccggcgcctacgctagacgccaccatggagagcgacgagagcggcctgcccgccatggagatcgagtgccgcatcaccggcaccctgaacggcgtggagttcgagctggtgggcggcggagagggcacccccaagcagggccgcatgaccaacaagatgaagagcaccaaaggcgccctgaccttcagcccctacctgctgagccacgtgatgggctacggcttctaccacttcggcacctaccccagcggctacgagaaccccttcctgcacgccatcaacaacggcggctacaccaacacccgcatcgagaagtacgaggacggcggcgtgctgcacgtgagcttcagctaccgctacgaggccggccgcgtgatcggcgacttcaaggtggtgggcaccggcttccccgaggacagcgtgatcttcaccgacaagatcatccgcagcaacgccaccgtggagcacctgcaccccatgggcgataacgtgctggtgggcagcttcgcccgcaccttcagcctgcgcgacggcggctactacagcttcgtggtggacagccacatgcacttcaagagcgccatccaccccagcatcctgcagaacgggggccccatgttcgccttccgccgcgtggaggagctgcacagcaacaccgagctgggcatcgtggagtaccagcacgccttcaagacccccatcgccttcgccagatcccgcgctcagtcgtccaattctgccgtggacggcaccgccggacccggctccaccggatctcgcgagggcagaggaagtcttctaacatgcggtgacgtggaggagaatcccggccctatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtctccgccttcgccctcagacgagtcggatctccctttggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg  b›   9   ?       >   M   H   -   0   B            <   6   <   @   ;   F   *   9   D   E   /   *   $         <   .   *   &   /   G   1   *   J               %      %         $   %      4   $   &   9   P   D   '   .   Q   "   -   E   ;   J   L   B   5   G      8   <   O   4   /   A   &   &      )   C   C   -   D   =   .   6   C   e   ?   +       /   9         5   1   -   -   %      %      +      !   (   +   !   #       6   )   1   +   !      )   >   3   (      4         %   *   5   5   1   A   L   ;   6   ,   3      -   ;          #   '   C   9   R      !            ,               &      !   &      "   3       $   0      &   )      /   "   8   '   %   *   %   .   "         )   ;   .   (   *   9      -   -   '   4   4   4   '       (   B   /         !   .         (   +   -   -   T   8   J   4   W   ?   <       <   2      "   8   $   .   $   G   W   2   /   V            (   +      2   9      7   8   I   0   %   $   N   D   2   0   K   Q      <   :   ;   >   .   A        9 ûQR}~Ú%§!"#0!	b±uÄ¬­Í˜�ŽŸ ¡¦ÍZÏÐ®¯�ÿg � ˜!™!š!]$Ê$L% (<+N,<-õ-ö-? ¬½Sf«î½-K�{¨1¥1M�	Æ	ù
XæK¯%IsÅ¤Î“s¥�¢× ‘ Ê ›!ô!"�$Ë$M%J&%(õ(”)ÿ*Ì+-Ã-÷-  – é 8C&$cvÂh%™§·Îÿ98tM‚Õ!^$(¦+,O,+-5-..> ü¢`°Ûöõ{"	O	†	3 Y²êk‰®u)°cR™÷z[ìßëúEüPbÑç^°GS  h u ¥!à$’&ù(U)=+Ô+-=-È-Õ-M I 	#.T¬­°³Æõ4L[ˆ=Í2�¿V	
+
š
è
YjoçÅ]jet}1¿D�¦èï4£‹©Ðæ>ìï £Ÿin’¸õ!Ò#Þ#Ì$ö(é,-�-H i ˆ �¾g€]r.Uÿ0Okuè»2ÿY	Ç	Î	â	:
P
²
È�¸|¡7J*óWÆêtå+dÈzÜØ†ùB ’ ¡!	"{"Ï"G$ž$X%}%&K&€'(Q)•).+µ+Í+Ý+Ä-- ¡ 
G„|ôû©	J”£Lb¥ÏM›Z¶/�Éä=\tV¿ =!N%0&	'à'&(A( +M+',-ø-0 ¦ ­Öï¾Ž©¦N	’
ú
!äè°&SÀÆ”hÂØ°=¸Í±›Xe'{•á  b Ë ó œ!å%T'B f q 9ÊÙŒ¼	
di�jwÖi©ÁÄ|Š¦�Îï&šám¸Å ´Üöù_˜˜ÇoŠ´ƒ×îÙ‡ _$Ô%z&#'9'³'Ú)¶*§+Ã,Ì,,-6-u-Ð- * t jx‘ Eþ%ÏÑ2Y!V"%3%m&Ã&Ý&''_'Œ'­'í). ó rD'Iá“
É
Ã:”Ü"¥ûß!é".#Ô$;%¶'*7*v*,P,. — ê ¿	ö¸ó%q$¨â9u�NÖ!	$	%€&(-(‰(f)D*ï,<  öý aºö|ƒ/	G	¿
ö
¡ÏVä¢ÈøsËàãŽµ¸ëQ„‚�±3qÔ? Ñ$á$%0%–%×%ö%S& '*Þ*ô*>+Õ+ , -2-¢-É-î-.6 Œ ï£Üí÷w´ç>#	l	‡	4¬ZmE…*±ÝG^S¤ì{¬¿ì[ýc\€jHTÌ v t!õ&›'¨(Ò)|*¹+O-< Ü&Ý±ù@8	P	

ÖœÓzv]‡Pdöøì\FLj‘‡k_ã¸½…i n § !¦!ÿ!S#Š#Õ#%¤%“&G'ú(/)ò)>-B-´-@ xÈ™~³	ß³ëØçîªí;lŠ¯ÇÔlîšS„í›ûÛßÒ­èÄÏçý)tÀä !!I!§#­#¶#á#ö#¿$m%x%Š%<')V)a*¬,Ö-<.; ôù$p®±»®¸>¥‘W	§	º	à	
N
mWÆÔCfKÀE®;¤ýX‚é¯Ùí}„¡oÕ¶Í"¥#«#Ð#Ó#ß#Ï$Ò%'¦(÷(ª,F J L Â r/13>UL´Ç“ÎÐÒÔÚÀ¦
é
kpèÀø^k~2©Î/×éðq-—ÀæŒ•ªçp¦¤ ¾“^"Å"Ë"ñ#Í$3()Ï*]+ê,d-‘-* 3 A
ö\‰q3J	q	u‡œ…§Rî5\˜°Ñ¹Ój¹8!-"Ç"i$Ò&,'‡'(�)*¹*å*f-9 
Æ@­v&5M¡ê,
›
ë
Zê©l‘,5Ž—×9Æ?°ð4@¢Øx´î!ö!½#B$m$%e%µ%'Z)ª+#,-V-D j ‰ ä+Ú^sÉV¼¸ÁÄÇà�	—
wzÉàç+wáô4T£Ð÷,AÍÐ{ÝY™ÂP¨‡©úÞ“ ¢!È#H$&L&4'Q'p'é'b(R)a)–)W*¶+,Å-E N �³¹¿h�…Ñ 1•Ñ3Z	_	Ï	;
Q
_
¨
³
{¬¹Ý}¢½ÙX«Þëò1ë”^ Ù	&“!¸!|"¸"$Ÿ$Y%Ú%�'Ø'(/+A+Þ+>,d,{,Ï,z-“-ñ-/ ² WÎ/òPv¿ÖàéPl¼7] 	È	ã	0
18K…^Ç5euÉ^˜Ò+¦½"º$F%Ñ*Î+æ+3,* ª §³ì¢lÚð®ù*rPžú<€°u¶æò³	&F¾ÇrËIC 
"Ð"]%~%Ÿ&(+$ 0 5c…Üª	ƒ
GKÂgmc¦ô[‰¬0‘ÆÊåßBö¥*i+Æ,-‡-ù- Ä Ý HNl¶ï6}„üô¤`r3=ZŽGTWO%ï%1&ç(ð()+(, b ¢ · qéãÍM*À 
'Í''(5(6)[-.< y ý t] àõ·“	ê	F
F–Y•‘ÐNiœ§·ÙW>]dc¬ç&9u"À>!~!À!é!`"–'á'ì'ô'B(N(·(**L*N+_+ƒ+Ì-. “ § Ðouû(rÂ		ÌåÁê5Å7ÙÜëº€’²�Y›ÚÝ|Ïì™ Ì 5!ó#²%Å%(r,É,ì,,.9.* œ äðUg¿ƒ�¯ÖÜ?Nû
’·TÌ~Ó~±½‰¹!œdc | á%â&U'Ž(Ø+Œ,Ù,-& d×§O“

"»îz'•i�¯ ªÂÎî.! k!�!P"Ž#ç#û$æ%ç&×(²*/ ø }®‡¨“ª�Ö	û	�é±ÇþÃØ¯s™/>è+o$%fµ(–?•âõô d!ä!i" &±&!)á*G g r �ž+ý‹ Ëù�½	
)
æ
ô
ª�¯TkQ{ªÂÅ/XßâNPxÆ²ÎÝ÷ú<`–™êVžr‹ lT¾Ò×… y",#Õ%Q&7':'´'(d)Ø)1 bÌjîÚ¬¸	D¹Nu�xep×j§ ð‡›P)Ý$m@Äå™$N"É"Î#$k$c%¤(°*·*¨+Ä,Í,x-*  OQ`‹;†BÌ}ÚùûÚA‹ž xåpµÚãˆ ³ ;"="L"w"$R${&—&â(Û)h*Ö*--7-v-J Y } Ò CS:=—H+Û	Å
ß
e�™Îj¡ãŠY‰’žÜCLp}?¢Ï'M*¿7Ìün¹µ²»ZÈ`„ØïÜ/"?"`$©$&™&$')+*"+w+i,h-Ñ-ü-A.   Lá+àø:F<€{!8"Š"�"Ë#j&}&'�'®'ä(£) + m kƒã^_s	…Üý³ÐÒW"$T$4%ƒ%Ä&Þ&'�(Ÿ)Z*¡*l+þ,Œ-.2. Ê Hž’!ÿ‹Â	Ó�^3m�š¦"C#Û$%n&'Y'`'w(î)Ø*7,£, u y^&—¸ëˆX
A.�êðç«»ìZ!Ð!»*_-% ]É(Xƒ	©Tœ•ÕA¦»Åür Š µ I")#‚$�%‰'Ð(Ž)À)Ã)(*P*^*ç*Z+ã+/-À-./. 5 ô s¿Ís
¯]à!ê"$$<%w' (’(®)*8*j*w*,% ü	JU�â59”§Ñc	Ä$«w¡;ÖGLåÖ"/#$Õ$™%ù%·'¿'e(µ)é) +¾,. <E­	Ê
ï�Kä*ŸSÓÚ ·Ý#�"s#%&v&„&¨&.'Å(¦)*5+e+Q, \L	1»ÇA©âšãF[v¦0]Ò� :!š$¦$
%�&ß(æ)9-$ ‡DÈ+³ 4¹<ù%…zt:ÆÈ s"–"
$Î%.(Ý)S*•*Ç*÷*ð,-%-'.% 	  ˜ ë Y�Öt
÷ô-&rŒÌAŠ‘6O¬"!×!E"O#Í&(Š(¼(ƒ),u,µ,ú, À	
P±¥Ò~—o§pàk‘ÅôIàœ Ï Ü 3#8&Ô&g)E*4 þ!O—ß }Ç
÷
 )QË™áäh�¶…–6yˆŽ¬²Úr¶@ È ñ !!È$Ò$%%1%!'±'5*Ü*%,-)-3-M-s-Ó-$ ·÷<a	H	.
ìåWßÖÕŒEWb�ìR{Ø%Ø%'µ()*ß*?+Ö+Ê-ï-.&  B÷„s£Ð+O÷
�ÃÌ¹ãèþY¤4Õ !€$Ù$Ž%—%÷%O&õ*ž+¡,¼,#-Š-9 ¡çéb»'	0	<	À
¢å÷{£#O�ÉpùXt}²?ÊWƒÉëXz|œæÆ …$Æ$â$%&T&¸&f'Ó'\)¹)
+V,º,!-£-¸-P ¿ ›Ó¨¼(ORd™œŸäx-µèž$	€	Ý	C
q
5g–Ó.F2AM¤Þû>:ÿ‰þ*M¥Ê
&|÷.dÈ�íUu!‡"Ý"¢#î#U%ö&ù&'Ç'Ê'Õ'^)e*}*+à,-X-D  # 9 � ð¤.x“½ÌîÄÍøHu†
Ï
á
­þ[Öô‘Îã[Ó«H9@hT­41úEkðI£úÍï³"ö"g%r%œ'Ã')?)l)»)-*¬+º+Ä+º-.' [ º ?ÃÝ»
í
n‹+²þ_œUµí7a·ÿ¡Á	Ëñ ü"#!#K$²$·%Ó)…*‹+
,P-œ-. T ëŽûY=?m	ˆ	ÚH»Zfù†ÑH�ƒÀí\~ÀþAGp§õ]ðèÞw ›&©(€*y+X,j-‚-Q áÞr«úE[Î2	5	9	
�
8M\_¤¿Ð×Êà{»¾ý	r&^",emóMjÙ6½\òBä\©é\ _ o – ¨ !x!‹#$¯$ %%“%g&�&”&µ&m'ª')W+?-µ-ë-þ-H." '¯ô²TÎì»,Œ¾“}|Gk’ÎÔˆOt× §! "Z#¿#o$&'H'™)Ì)ß-- '8EÝa7¨AdÔÊQ‚S"1MÈg‘¾_z†( Å!Ì!"$"1"à"Ö#’$ì$)&V&›(û(ó)¨*ö,C-E Ù Èç+£)	>	Q	z	›/�S7CwDPˆ•.”÷ùhí]Ýû5Al`b¹D j « !ø!T#+$‡$ä$ô$%%%¥%È%&&a&ˆ&h'�'
(()0)â)ý)<*ê*$+ã,; _ · 	Â
§û´ñg4@8èT!?v…‘¤ÉZ´üÜàåSbéøû…œ»ÐèZu~ÌL !J!¨#®#D$‹%&&N)W)‘)b*Á+-J yšÅ	g	;wÂlèïøn”«<ENmžçâá¾Ñ ¢¨àåBˆƒ¤;‚6 ´5Ñ,* : ¸ …!«$À$n%y%ï&ü&s'J)ª)Æ)š*+k,¥-¬-ç-.=.C.L @  Ô -<ÉgJ»ð 	k
ò«ìÙò8ý ¤‹Õ!ú"1aOö¥Î´»ò§®·î'vœyÞ/ÌþŠgO S ¯ !!(!M!U!ð!"("±#·#â#Y$b$<&º&='Ó(x)×-B U£´’jC	
 
Ú
‘à" Þî°ÈVDmÁï%p�’›pŠry ,lÓ®ÁÅ;†žÚþÁX å .!A"b#n#x#ƒ#÷#Ž$ª%­&)ð*­,-5 «¼ú|ª¼¯z¦/XétÁ$Hgr’¯Œö¥þYêù~æFLf —!¤!"K%$(ø(T)Ë+Ó+,M,-Ç-ô-.G H ‡ Õ-	F\q¯²ô3T<ºX	¨	á	
O
™
±
inÇœ·ã\{¿
LVÅéÁäCîy¯<ÌÛ<[°î…¢à·Î"Ñ#W%|%ä%'S'ß'@(L+´+�- p HÉ’»	
Õòp¥ÄÐáõnÖÓ%l&&'8 ‹ õ%wÜ}¹ì?v²‚k	ÕÞÒæíD©yãF¡í£ƒÚüpËs!¦#¬#Ô#à#Ð$/%l%w%‰%£%õ%'§(Ñ)*¸+Ÿ,«,¡-³-.< K Á qÅó02?Kou%’pÏÑÓÙ é¦	ß	M
ê
léÓ›Í.„,~¿�–è¯ƒ¡]"Ä"Æ"Ì"¤#ð#Î$Ñ%'+'†'œ)U-e-O M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\ß^	§
)qzyßù ¼3¢ªÏ04@têñ—Ï] Ÿ˜ÁEq§Ê¥H’!·"Ç#E%\%P'×'è'`)V*Ð*+=,z,’-4 Ã ü s4\Mkµpîß¶â’	E
F•Á_l�h¦Ø<b«%8¿õ)}!¿!è!_"î%Ì'ë'4(M(æ(5)¤*^+Z-†-/ ’ ÷ |ãTf†§‚’ÕÛ>MÁú	ËËý4}6r®Ò}˜¹.ç$”4!c!ã!h"æ#ò#á& )ë,-A Ñ BNŠ�Ë*–Šií*«(
ó
A˜¸Ë|ÙâøSdXˆ‘�Ù.oLW†)6ËO(wÜ±k.":"v"È"Í#Q$j$6'(£()c)g*Õ*!+h,g-@.& l KG�*‚ßâ÷]9;Š–·êr	-Žï]ªº7"‰"Œ"¥"Ê#X'v(€(ž)¢)Y*º*& 4 ¾WûTr4b	‚	#v®¨JS›ÕÒÔº�"(#r#u&-'v'ˆ'd(‘(Ï(¥)­)´)*]*æ*d+.   †ÕÇK	s
 °0@¦ß�™E‰9!r"™$Í%Ó&‚)Æ*&.) ¶æ AN–ÿ&	-
ëö	Ôz‹N€�˜g±5£«ÙWyµð %N&'°'´([)4*�+$,-(-C 8 S š§-w’ú'NQX›žÂãÌG�p
Î
ì
•ÍÒýþ?´)G€É%6ö0@Àùï†"õ"û"#J$f%q%¶%ø&'Æ'É'>)*+Š+«+	,-W-C Ø 7Ç®ó`6æ§¢ëy	œ
7L[cºß6BCO’-l�“ LRÜiØÇÍf�ñA • w!÷!#"ß"Y#¾#$n$®$$%&`&Ž&�'˜)ü);*â,õ,ê-G.- ,fïŸ	ª7?m áùà½ÿoŒ§³ßä+:xŸÀý„!ï!"C$X$¬&û&r'I)M)-D G o Š »,vÛE[¹Èj	˜
è¶[åqxâU‘¤Äè®Bíxì¢ÚõZÃômûKßr!–!£!.%k%v%ˆ%R'Þ'#(?(S)*K+·+Ê+Ò+Ž-Æ-ó-.= òƒSjt…
$ð½ÏÔÞNÂÅ5[á]	‘	ù	xÊÞü�gÌ|-3–ÎÑ|
$®#G(b!‘!¾!¶"[%í%à&…'ç'ê'£*y,. k Ð J�ÊÞúa	@¯{Øá÷cW,n­KV(I¥šÛÔ©ˆ6"É#P$Ì%5'c(u(b)¡)X*\*Å* +g,.6 R +6µåM¦_•Wâ¦œx	KÌõ5AÑàø¼kÞã$QÛhõ¿ªü” """ô"#I$W$&M&�&q'Å'—)3*, --F.C Q 5´º‚DR€Ý	#Ó4Z\	`	ø	?öµfm¬ß{­2JìH•jë¡#ÚÚ'�!•!!"µ"ó"#O$V$-%Z%j%u%‡%ì%„'Ý'>(t(2*+É+f,ò-e O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqryDW[	<
`
Œ
>…AB­Þ‚ƒ£¤¥¾ÄÚde²ógê�!”!¹!}"i%t%…%†%¾%¿%‚'ƒ'Ù'Ú'Û'Ü'(<(=(\(](/*0*1*+0+B+®+¯+¼+Æ+Ç+È+?,@,e,™,š,Ð,”-4.? ’l‰�ç×çc–ò(jszEXwÐ	R
a
ˆ
©
´
† ](º„“Å³ìh_®è
žº!~"¹"ï"##û#$À%W(^(j(½+ß+A,I,›,{-•-+ å À•Ò{3ÇUf=
�
|8C®ß~œ¦¿ÛUYôÚÒ7# $Û%ž'¢'(ƒ(D)1+C+°+E,|,Ñ,5.  lQ×ó3ò.YxU)9L†i™`édh!º"æ"@#f$·$_(˜()¾+à+4,/  â 2Šè%Ø0`¬Qm½8D±	S
‰
^2”™�6Ó»!"¾"ð"ø"#6%A)±)Ò*ú*+Ï+ç+þ+B,J,œ,|-–-9 ³ Xm�ÂÏè†¦—ž¸áê)^kt{	É	Ñ	ä	1
b
ª
‡u…Æ_´Èj_E¯,¯M ª!#’#ü# $1$|$X(Š)‰* “ÂódwÀFµ
‡»ífvÊ§Ÿë "$»$G%Á%k(o(Ÿ( - æ ´ñJã
ÿ‚çó´'6È‹3WÌÏµ!Ã$R%(½)	*2+.6.5 % ; � ¨–Ó|£¿m›ÛJgau	#
Ñ
9à=BÐÜ±ÕåvõBe}Gˆšü‘ò;$^%'Ÿ'±+F,1 mÎ4Vdú´	}
s}DŸ�§�ÏVZ™·µÓ¿9J;D "Y"®"Ñ"8#h#r$Æ&A'(„(ê(n)+D++G-¼-- « Áù0íÈŸ¯>
Ž
Ô
+Ç6Q¯ûÀ]=;ÛV¼
s¥ñ"¡$%Ü% &Ø&£'E)Á*n+},’,Ò,- ( Ÿ 6d ^†ô£×ó/y½
VHÃh‡§\"jÇÖaê‰§CNÍ÷ƒ¥ ç"ˆ#$ð)t*z*% 1 ¹mØ4›è	�
¤
¾®õ´­Ã1’Ë9³ó´i!»"g$¸$1(`(}()*!,Š,Ç, Z«	Ù	
V
L‹n:?m Š	àØ?R”"A#M#a%'&*j+á+5,ú-%  > ] R�Ý	i
„
-*ð�ûMdÝT<šæ¥”er #™(˜*¦*Ú*¿+Þ,-K-q-ˆ- ›Im1”7Rgn¾9EýÝþ
4>[·ù"$¡%^&Í(²)Ó*+K,�,+ ã 3�#OÕÛað%1Bš²	Š
&@asšÊ�ØUœ¼!"¬"ä"ñ"#M$P%ê%è(B)‡*+Ð+C,—, Å ‹™!·ÓÙ#~˜T
3¥‚ÁH¿"y({(ÿ+-,o-!  Þ é&­Q…õ_‡•�7{�ÔX>$7%ð%2&ñ()û*+è+î+),}-—-( c £ ´ ¼ Ç 8ÃéŠµr¹å%o
ç„aW1°+w 7 Ú"!$}$Ý$‹)É)++,,\-+ „ JY‘Ðñ‡˜Ÿâë*‡ê_l�ÄÑÒ	å	ˆ5NÇÉ°ž"y$´$'Î'6(Y(‡),�,„,�,â-	.! Ì §!9|—	Ê	«
pv†kž- Œ¨"##“#œ#['((À(7),/,9,\,# n¸-€åuä	2
c
§Î`µ`ˆF…N5€ Á «!¡"##|#Â#ý#2$ø)Š*Ê*¨-¯-  z ^ÁŠ�Ë¸›Ñì¨[e‡­£è,1gÁI ¼$Â%Ê&ì&Õ)M*Í-6 ÖAßxïG”	G
J
ˆ—P¼´jÁHSgXu¹…'oÁ"þ"=#J#$!%H%¹%9(l( (;)*m*(+,‡,¥,R-ž-) þ ”¡Åeö¼ë	y
‹ZOØ-wÚ`ï^cv?!!Á!ê!€"™"E#p&b'â'õ'C(p(¯(¸()O+„+�+1 uÃýôáÈÿ	¶
ï
Gb–EÕQ’�î¸Ëã÷?J‹d*·Ã:¨# ì a"]#'$?%¿&—'í'O(É(t)~)*�*`++ ” ç ívòüKŠ	šÍ æÂë`ˆ–Æµ7ÉJŒ³‚ÍZÅ€= ô#9%E'þ'ó(ý*Û+Ê,í,:.! . w ¨ µ}÷o	]

/ƒÚì»“n­×Û}²6!¶!@$³%�&å&(î(
*¨,*.7. À)ä
?þèÝ(?>ÂXœÞÐÐš Í Ú (¾)3+s,-.)   ÑpsÃÌ~		Q06ûKô8n� z�€4îUšMZíÄ$S%Æ%e&Ñ'(&)à)å-.> � ©ñ(�{ÀÓn�°×Ý(K&
¯
Üa“¸š¿áÑÝë�½r¬ü‘Ÿ²E~ŠþŽJ`Ž�÷ód C%â%')'V'�(Ï)²+ó,„-3 E à å÷h}À„¤œ¤ÜSbhobv	Ò
Å4€—UÍæyCº!‰"½} p!í"#
#/$9$¼% 'G,-( & < � —Ô@O™ºíü
`…>C²åêÖÔÖƒ…£’/e<$w$_%*++,Z,�,Ü, V{¢¯$
:ƒ(wöp¾4fH•›ý7$ã&K'Ù+Ú,4 ¯ $ë�Bµ	”
t~¼ïE ž¨(ÐôWh¡[šìž«Jh–ÔéÀ/àøy ž!Ò!"#‹$ø$ò&ÿ&‚*’*³*€+a-½- n[W‡Z
~
âj¸6Ã‹<"Z"�#ç%Ç&B'M'ë(H- `	¨°PŠ	#<»¶ÏVï©" l!ˆ!¯"Ò"è#è&…(o)+”+%  eØÏ5±eû){‰‚–°!:KE ¯!Q"9#i#s$ü$)%(Ø(p*½*E+s+ê+ð+* V ‹°�
°<ÄÓø¼Kép¼Ñ 9ÿ_q¶)=-ÃÉã€%-&²&§'),)â*+T+-™-5 ¬ ù ÂúXˆî?É„ÔA		ü	,‚È<CÁÈ>9�<Ü9«Æ†S——@C
 e!å!ò%¤'•(ÿ(F)Â*š+~,l-5 ¯©€˜ž×Õ	?
/oJêü²^·ÿH\6‘Ù°€òÀt~
%2^Cr–¦ê » õ \!¢$4&z'I(«(n,“,Ó,1  ~1ý” « 	Õ
7R— *}tš0?W½,Âïbt�I»&gÔòöò"j"Ý%!&¡&Ù&")o+{+A 7e¡í,BJ_Ù$Œõ ¤ô0zŽ…	Å	2Wa°J®jˆ£«Ìt($¤bQ˜yžÖÞDûOasRþt Ô!ó!\$ß$‘&¥+Â-.L h   ¥ Ž¬Åþ/NZjtƒ‡çÌú¾U	Í	*
9
ç
 IÄ“¢i Rd|)0šg¾Yc�µç.È×ã·3Š¨Ï=šëWŸ”øm‘Ua ¾  !z"Ý#&(-+; ) e s ò i�DØ¾	
õhŽ$¨ÀÃœÍî#à³Ûø^—!í1¤Øú† X!Þ!U"è"-#$'8'^'‹'¬'µ',(ˆ(e)Ù)ì)u*µ*6 ŸÇø³æ=.	7		
¾
õ
«Ul×Æ†Ü]kOõëÇëŒÎæ(„¿Ó¦ H!þ!R#‰#•%Ö%R&ô&;')ñ)`*{*1-A-í-, 2 @	º­·¹	¥
¿÷k†J¨Q+4­:�—8Å×µí!,"Ê"¼#Ï#h$l$d%Ñ&2(~(¥(¸*Î*\+©+",c-3 ± ²ãÍë»Ùkï­�	–
Ov«Ü;Ø¯vS]öµñ“ÌÑ*²%O½Æ%¼"$¹$3'o'a(å+,2,Î,y- Ÿ5Ûóé	‚
EÌfqˆ«2VÅYÞAæ•'ó')*‚+Å,- › cntœ'qÕ	€º‘yéœ®Ä©Á*n#š´ô-ë{ ˜ j!O"�#ú$±%(�(Ö(±*q,‹,È,Ø,; PR_aŒ:<üGÿ·	Ú	Þ
CŽÍMŒ®úo‰zÛ@BKŸ¡ûw±lq#S½Ûâ² <">"K"M"x"+#$$b%–&˜&**¯*w-û-   É à]‡W
ÛüÒŒ
æl™z!Ï!B#S$i&|&'ã(×*k+6,ý,^-1.  \Ì;È8Ð¬	ª FRÙ¶@äq ‰ ´ H"Õ"$#$&¾'�)Â)'*i*Y+â+.-¿-# Œ[
O~;}n‹„ojyáó«Ç Œ •"2#N#¥$7&»(Ü)R*”*,ù,8-' ;Þ	;	Æ
r¢ä*NöÞÿ~(DaÂW|•ÉÅ !$„$Ø$%%&·&e'¸)Û*L-r-‰-·-Ò-C  " Z ¾ >˜Ë<,Ü	B
…
º
à
fÒÙG-�âZŠºYe@£Ð=›8TgˆýL	}¿F¦ÇôDðÝ²"Ü" #¡#í#±$š&Â')k),*„*x+ß,i- .9 &Dàª*DSZ4	^š¾Ï.+É‹º½q%”!+045¼[aC^sy¨è^ ª Ö !Ä!Ë!"0"’%%'l'š()Ë)§*é*#+ý-R ? ^ ~ ¶ Ó ;TI‘B	f	
j
Ÿ
Ù
:v�¦Áñú!kðfñ÷ü3“Ÿ£ÝDM0U`NÐ¡ÀçÍ‘oº>£¶&Ÿ³R…Ùf 9 R W · 
!'"@"a$�$ª$%&Ò(�)Å)™*ï*À+j,-B. † ó2;Gu�sÏ"¢%k&~&'L,ž,! ö p)[±ÏâJenío¿=Þèÿ5\¸¾~|!â!\"å#O'L(å(›)<,   M…œá•V8Shì:‰Æªÿ
?9"q"‹"Ž"'#Ì#Î(¤)³)Ô* 7 × ™,ùFþîo
²ƒ!…"ú"X#$_&'Ž'¯':*+ n Ï *Lu„M›ÝbËŽ�ËôÓa!½!"ß&"( )[*¢*Ñ+x,ÿ,�-., ä 4Ž“PÖÜä
bñ&Y÷	‹
'7´›±ÙÑÙ�Ž! "ò"#N$U$„%ë%V([(i(s(‚(C)+D,˜,3. Á$_«·2C†tc©!å"‘#$e${$¶$5%ž(‰)°)ˆ*+ , lš`t	³	|
þAV�:"X"­"g#q$Q%Å&'@'é(m+‘,F-.  Ÿ¸]�¢Ø	ç	
U
h
€
Š½ŽlÂ²>Q‚³Ÿ#'|(ï)y*Ù*J-p- Œš "ÒÔÚ“"$f—™ÉŽz›«"ã"é%x(z(–,& ƒ Æ Ë I7‰´ä,ŒÃÐ
4¦ƒ04v6 �" "§"Ù"›#Á#Ü$Z'¿(†) ,,,.,8,ƒ,á- ‰ €x
ÔÀR_InÀ"D#I#\#&$ %>%o&¾&É&ë&a'8(®(:)s)l*,†,¤,! v ¿‰ö\
.P/_ý•>yIm¬Öí±LYÙ ?$8%D'Ð'ý'í(ò(ü*ä-& D ß ö'z¡®'Ran˜¹ì®
3`–Žä'o«�Õ_”�¼o!ì"('J'Î)**,  ê_†¯Y
ˆºëèŠÑ!‘*¼*“+é+ï+`-" ÓÔ	B�8|»ñ8Å}	1RaÐ
[!ñ%,&3&y'”(þ()+S+~-˜-3 d ¤ ÄAI#MYsæC²å<„	Ä	Ì	8
gÖI­…½Ìb£´2�ýs G!Ü#Þ$]'Š'+(‡(ë)_*,+0-Á-.  ?ê¶º&pÔŽ	öèuIRªUX¨±–Ö,+"Ð&2'”'ò'[+ä+,1,$  È ^9:‹þ7ˆ yƒòE"k˜¼Æ‹ Î!J"Ô"*#1#"$½'Œ)Á))*Q*,ø,]-0.0 ! µ ½ :ß©Ê);Ye	
ïÈ,2¹ S‡=%3Bx§ç 8 V ¶ Ê!&"±"Û"ì#~$ƒ$×$‘%Á'Ñ(�)·)Ä)Ê)è*î* 6 … õ „ZÎdòìtëÅ©n
r±‚!á!p"'9*;,& Î )Kt’À™ª¶Lö	6°ÊóØ9b`!�!"z$µ$!(U(Z(h(�(ˆ)¯)+�,E-
.)  ‚ Ñˆã+ˆŽ¡–æ	
w
‰È/²œ"Ÿ"ª"Ø"â"H#š#ž#%$=%½&ê&7(9)r)k*x*,,,‚,…, C  `mÒÓ	­
O&n^Kn!ë"+&x'Ï'“(ý(*�*R+’+ã-/ 9¨":ýXä6;Ód	�	Ë	7
fÇõ‡¬x¢³Ÿ<ñ$D!jæF!É!0#Û#ë#Ö$\'¼'À'ñ'*(¶)ê)0," Í ƒc
K~•¨¬
qmò.×Ja±_!Œ!o"©"×"™#�#T(g(8)q)+‘+,:,8 ‚VW}ã:ÒŒ	˜	ÅÆ%lõö./MI�Š!‹!Ç!È!n"####”#•#–#—#˜#Ø#Ù#Ú#ê#š%›%¸'¹'º'»'ø')(S(f(ª*�+ø+ù+.' bŽªR™	î	&wÔ÷0HNˆŽ $ *   ##$”$œ%ú%?&X&ù'Á(«*–+¡+ú+],±,¿, .% o¹æ	ð‚Z†1UIÔXi“Û2¸% á +!þ#%G&w&…&}'Â(§)A*9+f+²,À,©-Ü-* G¤.��v®	Ë
>€ÏxÚa‰	k(Êñu« À‰¬!3"‘"¢"##©&F(Æ(õ)ù)‡+—+û+°-% Fcåš	ó	¨'aa¸„Ñ+ OTOO�®6�Â Ó $#}#@&Y&/'ú'‹*¬*Ë*6+¢+. =«Sï	3
d
%¶LGÃåÕøyáOÞ$�| + � ¡ ø ü !t#Ã#$3$•$è$î$�%û%&*ô+R,^,!." ÚpýM	Òñƒ[ªYé\hÂ1»l Ž â ;!´#›$½$%%H&x&~'B*:+Á,:-Î- Û Îçù‚ò\‡Vä®Õ¤ 2b§ÓÃ%g+ { ‹]¥Ÿ2íãJ”G^ÿ#§$%&‚&Ë&Ã(à(Ö)ä)ç)N*u+³,) _ºÂÌ¹	œ¼©ÈBfˆ2_›jÜ-3yÏöw¹9& J ­ ,!ò$þ$†&í&¨)¸,ª-Ý-; zˆE×¥�´�	K
Ì
QÐ!5yº=§ýŠ
–uß)ËvCÉ 2!f"t"£"Â""%I%Ï%s&ª&(¡(²(<)ú)T*ˆ+,-&-S-Ÿ-±-. 0HBjàwð,H¯	!
?YúbkÂ—Th&vc{7†ò¬!é "4">#+%Ê%å':(m(*¿*ø*I+ü+( 7/É•	
H
‰+ÛFR Y†õ(pŠG ’"—";#K#$$\&/(Ç(ö)r*–*È*&+)+ì+,ˆ,* Ñy‚
|	˜�½µ4I	lº;SÁÇ­!ÿ"##-$u$‰$ö$'%º%c&(G(*)Þ)n*˜+¦,ñ,(.9 ™ ð ÿ ZgŽÆ×-h@	S	Œø‘©õb„'˜.�2ù_¡PUP’PÃ Ô !Â!Ü!ë!ü!F"S"P#º#c'j'(‹(¹()­*Ì*£+Ö,û, —5d½æz
1x¹	Í<PŽ¯ƒ"%#V#û'q(½(„)v,- 
   ¢Gì	ô	u
*0s·Ø$GP…Òð,B‹M7¯!€!š"F#æ$Î&0'’'ö'D(Ž*ì*7+P+…+Ž+ò+Ú-- ì î •ÊÌf÷›	![(.EÙÛb0adfw7�­#!@!Ø!Ú!ú!�"~#&A&Z&q&ã'°(Œ*G+,¶,' g	�¦ÓµyÛpMájïÆõ+â$™ ‚ !%!k#u#€#($é$§%&9&À&˜'u)ÿ)I*ž*S,4 éâTÉÚ£	 
ð
&H#M]—íÖR˜9¹àd²HlûKŒe¸Jn¢ í 4#Ä#4$–$@%ž%Š&Õ&Ê(2){))a+4 Ä>õ³¬+	Á	ð	
4
e
·
c}‹ŽF´ïdÝä¨(ÄhºzÄP%ŽF’•¡ � Ð ù $ï$&î'P(h)>*F*õ+4 vþ›Q²€U“9ž·ŠÌùø#qÇæÖ@’ùªý;©áßd©}, 2 Ý ý B!P!±!b"^#ü%	&C&Ú(* *_,å,".' • è PL	 	N	ø
ŸåÃr—¶Ì8ëÎ7]­€ � É œ$É$I&ÿ'ô(“)þ*;+
-*-4-;-Ô-  "óþ‘
ç6aò*Çåds&zžhA ò <!F$/&'P)Ü+&,è,-( qwýà~‹È
i·{‰l“—Æ‰�³ÛÓ$%%2%:%y&Â&Ü&"'²'*6*C*Â,Ë,î,t-Ï-B Ûîÿ˜	F	›Îì:Ó„\R«÷rš¾ÊâKZi��´·Þêƒ†[j¬i�Ãâ2s·¼> m ã !!!µ#õ#¾$%%F'š'.)Ý*ó*N-;./ ø=¤I	p	V¨BÖpí[–üWå”¯Öo¥®Ø|¸3?½Òw³Ô7!ª#A$%´%')Y)*ä*©, © ¦¸·ø/
^
æ0„àÝ]X¨Ý·!Ù%ž&(@+c,ð- / a x Ü b¶èƒXó�FcS!¶(ï(*K*h+Ë-.! Ï~®ú	í¶×Ûê¼ˆ‘í €ÙÜc~>ÎÄ%à%&°&æ&à*×++.8..  X | ø…Ä
å
©t Pÿ>O¾ÞMä#Í?ºÃä;Y•éU�_ÑÖ„ ¨$&P&á(×)v+ Á^@„²éë€ $Ú$‚% *¢,‹- Œ¦î€ã)žK\ÿÄ�$%�%˜%ø%ƒ&§&(Ä(¿)è)O*4+Ÿ+½,..( XC*²¤Ñ3,ø–ºÆsÄË@HßZ¥/5\ÅÑ› Î Û !!D"Ì&Þ(å)ö*t,´,-$-+  è`
Õ"PVÊoœâ~ç>z×ýVXx‡Èê{›åÇ  !!Å$Ç$�%Ò')	+U,¹,»,"-- ¹ Òê»�c¼Ãt	ýÕó1øLªú9‚3`¶þ -oïÊì
¢çùîT%Ô'])º)d*Ã+W,�-›-¹-- qÍÍ(	1	=	£Rü½É|ògú!{Ó@N[' [ *$†$‘$ã$ë$ó$ÿ$%Ç%&(&U&f&‡&´&g'©'	(')á)V+Þ-T ¢iºÄ	Á
7�æ!õC¤$‰ñ Aqux‡�¦­ÈYu‚£�5k³Ýä.4aËÐ÷ú+„›º:Y}‰�ËK N ® '!-!L!T!a#m#w#‚#°#©%;&¹&î&w)©)+¤-«-æ-.8 ªÔ{©S|ëy±.
°
hÔÝ›ÀÑâzìñ#G¨¾	oã‹  ;ËàøåEÊe J%V%{%ã%ô%'Ð)³+,- -²-.J ‘ À û {ÄØ¦� o‘‘ØÞLŸµ¥	Þ	D
L
(yE”»ÒšÊ3¡¥?sƒ;­—ÿ+ž}DaÉ7‚ô3!ç!g"Ã"£#Æ#ï#D%Ð%'*'Ë'Ö'4)_)U*+-T-Y-…-4 ‰œF½))Ô)•¶é�	'
r
ò
—·ÊR"/�Ø-�ÊÞN'v�Du"ˆ"¤"q#˜$t&W'u'(�(¢()�)¬)f*c+%.?.W ò‘Peš�ÁåË%	ž	Í
6”b¹6Þ>BNßüÓþyý>€Š’³(Fn‹¦ÈÿMK*fÌ/ew�ž¿øîV ï v!Þ"­$#%p%«&÷&ú&È'³(=)H)L)û)~*‰+œ+á,ô,'-é-? F Iñ¥Zi”áï¥ÎÝùi	w	J®×ZäVpû@ÃçU»'¤wÙâgô	ó#­"¾FlJûq!5"Ë%Œ&Ä'æ'*Ä*J+-.E.< æCy~ÅTcipxCVv‡
=„ÿ\õ@�’ÃTclz¬IGfié­ç"´"î"##6#ú#,%h%s%½%�'¡';(.*­+»+Å+H,   á 1Ák…¥�ñ-°	T˜€iD®L~ ê g!"÷"?#0$n(—()@)ù*ý+< $ : Ž ø/¾ÍžIIc"
Ð
Ó
â
Æ5Ï\Î�<Ôä˜´:AUd|»58‡Š™2ûñ¤Îð´!:$Â$×&m)¼)*À*~+»-2 ' = \ ž šÖ	£
¼
,ïú­>ÜS³ÿ;!Õ8ˆ¦ M¤×“Ìòq¤ “"L#‡#$`%0(*%*s*—* ,‰,Ý, ˜0APÜý
%†?ŒÀ¶×$=$L$ %]&Ì(†*+í+,,n-" » ð8†ä$n–	
oæ`‡�V„‹ #"#{#x$³$È)÷)É**+,[,€,Ž,§-®-8 Õü@ÄÞ»ÊîÇþ	I
î
ŠOaD³Pšë×,GâZötî†bŠ¸„¢)¶Â
+0fH ˜"ý"<#¸%È()})Ô)œ*'+Œ+Q-�-$ ì|Ën	}	>™ú‡JmŽ=ÁÄT™< d&œ&ä&(%)ß)Ú+§,).. �Òz£%
ÄÛ_‚„™¾ê¼éx
qûž3D‚ý „�I¢ö. #	#.$6$8$v$B%»%+Y,Û,ò,ƒ-$ ® #œZA°‰	(;áóg 5Ig•U¨ß÷x ‡!®!"#Š$÷$(%ñ&þ&L'o*�*r+G U WŠü >ƒ—@	.;nI–¶G[)5;Ò÷€J¿sª…»Áî]–œÿ8BHqºþ^pÓñ<,BÂÈé	  º ¦'H(ª(+)z+™+m,k-W ñ hÆì«�Ø÷.i‚½-	6	T	
1`ô’¡Ÿc#(i¢¿Ës™'f›Ûí#Žæ-ô—¶ÕêÚ]“å'Q�ì0£ù` ½ W!Ÿ!Ó!Ý!ò!ý!T"Q#[$”%&�&ó& '«')´*¤+@-ì-2 š °  ±âžs¬ò•
ªËÛ:…\Ä*3¬ÐÀN€¼)Å"7êz — ì!Œ#»#ù$°%n'(Œ(Õ(Í*�+p,×,b-/ [ËßÇûF\Ï¶	Ý
N�­©ÑJ|Ÿnúiv°Qkªá p ± y!G"$$¤$&6&h&•&º(“*®*X+ü,¾-V %C3	:	A	A
ž
¹
Ø
9]u¥½ÀÑØðù qFeáö)¢¹õX¼þ
$/_“ ÏfK�C`¢Á/Vž4|¾E{ÆóQC]Q ] © Ä Õ !	!!Ã!"#Œ$°$%%$&¶&d'k')j)ƒ*¶-ÿ- Ö o˜(°Uˆçíþ½Î}"["„"&#W#ä#N'K(š) 	X{
��¨!"f#�#d$p$?'r(w, 6\³eÏ×	g

¼�¿kQy
±=Pu5 [#À#è%È&­(¾(…)•,I-à-( õ®¾[
2-ã^ü¹”~ªº7Ä|=x0HQ`l“ÏÕ‰Œ	°Ø ''C'I'ü'ì(Í)+    9>Þ@HLB±Ã	îÕ+Hÿ1t¸HQ¼Ë‚R†§ 2—U Í!%"*"°"Ó"Ï&1'“'†(í*÷,  B � (©µ õ	m
v
%8m!�!"›"á"G#*&¼&é&œ(ü(�*Q+D-2 �b8a
©Q‹	í	6
eô²Óñô-ð#CH`i‡° # ) Ÿ E!^!‰!Æ!m"×#é#“$>&W&ð'÷'R(p)©*+�+•+÷+°,9 F£ò	$=`ÙY·ƒÂÐTj'NWxÉðht’ªà1ŒNŒ­¿{Ò à ÷ û !*!2"ç$í$F&|'E(ô)@*8+†+ó+Û- Ú ÍÙø¤üžñ^xÎõa8ºk ¬ ³#ñ$ý$%&ã)t+·,7 /yiÐ6	{	œ	
 
*X¦3EQ–üô•bÞ6BRF è 1!"e":#,$t$ˆ$õ$&%*%É%[&b&r&ä'((±())q*¾*%+H+ë+,8  í ï f–ÉË4,g?	R	0 �)/ƒ¶×#DF—/1øe;L®!!Ù!Û!ù!û!R"‚"U#¹#å$&i'‘'�*ë*F+ñ+Õ,Ù-I è²šfÙ	*	¢	œ"L\|Š�ìT´³8xÚ8c‰Üßøc±"'Æúiîg©¹üm c˜¨E‘” 1 $!A!O!°!j##¦%&&B&‰&Ù(1)z)þ)=*H*ä,0 		E	�
žäh¶59zqk’êöq½Ýcir«%�ág  !E$.&Á&Û&™'-)O)’) *ò*ç,	-% ` ¥£­¶U§µ
AÜoéZ•û
 ·>¼Ñ=vÍÜ©#ß%&¯&X)J*ã*b,$ W W±Ã
¨ƒ±•¹=ÅN½Lâr"Ê[:Tê.[ÄÃƒ C"�%¦&Ý(Ÿ*-N ¸ ŒhüÔò Ôùñ!Uð@tw†¥¬Ç¢µýŸÒá,nãæ=`Öùü*†Çé	ˆš¡ÊäøM Z ÿ !&!K!S!`#l#v#�#¯#)$�$ê$Œ%¨%'&:&³&¨')v)c*+U+Â+T,€-š-D ú Ãz€êÊ”¤	
ñ
'x“¶ÉDð"™É×n, Œâ‚Òx=ÉÝ':m�ÇLCe¾6äDî æ!p#Å#—$¬$o%z%ó%t'
)3)G)K)€)«)b+›+è-.$.>.2 Y�BUh	<ISƒÂoS€;?ãºFe£³è¬Øáæfó˜Kf!³!5#ù#Á$‹&Ö&–(*Ã*}+D.0 ûï…ãÕ#mÆÛ
	ý	¢
$Nîù¬=O™:¿ás‰‡¥ƒLµÖ*£ z#†#Ÿ%Ë( )|)Ç)$*›*,m-¦-­-K ­ "‰›ÿ@–Ê	-Ã':=m^˜é•àòFŸè:úI�2Cr”©üŒ�„<T7¡¹oÃÒ-˜+Aö  ; ¹ †!"5$A%ð&ý&¥'$)+q+l,Q °ÅÊªö�¼ñ,	@
¸
×
Ü
0óp¬dÚ9¡¸ "IÊ#e’ÚÎåÃ)Ïu�µ¿B¯»(.�Ä!3{DzÅ&�ë¢ P ° ¼ !V!ñ!$Z$£$¯% &&#&5&Ô(i)o, Õ ­Ö	f
ý]ŒûP©¼{w/_°4 e#ã#c$>'J(¬(”,< A € =€ ?K´ŸÂ	ñ	5
l
í~óGþ_X±�¦Áóiïÿ&wsß0‹¬Gh– T ž Ñ ß ö ú )!D!]!)"l"=&E&»&{'ï'Q(?*ö+¯,: .x3h™Ø	¡	

KŒ�ëW³¥²µÖ"ð27bÞ÷ûó&Å¨¸ÍôQÿ—§“0 ç !0!N!"d"²#¸#ð$&y)G*Ô,Ø-; V¤¢¬µD	ãT‚	”¸nð Yq”ús«¡ž	m<hªÕÆà<f‡ Û÷ÿ~ÂY þ R!B"_#�$Þ%¥&®&Ú&Ü(ñ*a,æ,-> !þ•œ“"l¡
R’µ&9!˜ßñ+:Ÿ‹~EwùrœÈç&1Bq“œ×‹òdK½Õ)Âãõ²!"o#y#…#ø#	)#)*#*p+|+#.. wÿ2	
Ö
Û
V!±ÉWÍúÂ%Ž¾Azþ-Ã .v¯ó«/ 3 Þ æ /!C!c"k"d#®%ÿ%
&"&D&®,A ¡!k³´áâ#$%8S�ïðuv$›@AX“ðñ-cuJ¼Ô'(âeŸªóô- . Q!c#„#«%¬%­%ý%þ%¢&£&¤&Û()!*"*`,  <ö  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       2                                                    
                                                                                                                                                                                                                                                      X                                                  
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                	                                         	                                    B                           7         	                              	                        (                          6                                                      
                           ,                                         
                        
                  '   	      8   /                                 b   =                                 %                      
         %                              *   ,   
            +   N   4      C   9      <   @   0   2   ì   …      C   9   :   ;   &   ¨                    2                        
                                                                                                                X                      
                                                                                                                                                                                                                                                                      	               	            B         7   	          	        (          6                  
         ,               
        
      ' 	  8 /           b =           %        
   %          * , 
    + N 4  C 9  < @ 0 2 ì …  C 9 : ; & ¨   ®š  °è  ±  ±œ  ¹Œ  ÂÌ  Î îÅ%-
€<ö
)é` ¤ªö
ñ
dA_¡!€ ÅÔ¿ùúqr¼úû{«ïñò<ÒãæÆDeÃöY ž ú !�#Á$o%�%'&>'æ,±×(An€I<Áy·›#�Êú&"û
Ì'iÚhr/+V!Ít ˆXà*U€l$±%«"’…®#N)¬-n+J	×ð«#qEƒ=D©Ì$™™ÃF‹Mèj-ª_¡¼{<çŽY²ÃÄß÷Å	'	)	0	5	H	›¤×ò[«ï+F‹î<E÷ý "DM’�pˆ®�·äãgpˆÁûW…²äuèñÕO S ¯ !!("¨#®#î#Y$…$Ù$%Ž%Ê'N)j-œ-£-¬-Ê-Ÿñ�:6¾!""ô–±'•]c ×(!)À±•]×(±•]×(–]•]•]]]AÖn €IÔ)s*Ú+:V!z%"I(]+:­#‚i D©ý	
=ŸâK"b:Q&:äkÇÛ]õN"‘˜’'&]n¶B¥û«6l
û)«Ýä$s9&ê¬¨Þé¯­®<ÐÑ«,ª¼å�èý é!´;!I*¨�	é' B(ƒ+!Éã	 
dpäŽ å, 
däŽ¬¨¯<Èª"â"üà#(ÝÏ™ Ì r,á<$¸)·-?
o·ÿ‘2CY!º* >¿
iä¢m¸´s¿ì[ý\‚ƒ×Y!_$¨(¢-)$—4Ø´%#,'½)2+˜	:RÞÎæ(sH!¾$`*;.lsz 	È	0
a
©
 „^³^+#û#â•
Nn'£'Ét†+=Á (Â¿
Ï5ä¢s€Ý‚3Ï™ Ì ô*r,¢-&	z("  _%‡Ü›
Æ¡™Ï,?`Üö!™&"+w+h-ÏÜ™&w+h-¢ãT	nY”ú	®™Ñy$´$‡)ìS†	�Ü®Ï¿™nëüÑ„ØÜu ?"™&w+h-(”›¶=
Æ¡O	®u,™÷[Ñ^h ö!�n	§,ž&t+ ¿
ä¢s‚¢-ÉÐ{Š[ ÓV0&',Vëh¡–ÔÒ!“µ+‹Èo#	)#.ßeA
Ñ
ªKŒÆy!h&''Í) &	/	¿
¡äz¢øs±‚Wá$S&¢-ü Ø}!¿!è! ¬¨©>¿
ßi±”¯Åí­®äv›‡¶¢=™ø=m¸ì´s¿ì[ýÐÑÒ\ek‚Ü"ƒ×Y!	"_$}%¤%¨()/)*P,¢-«½T	cŽæ�è¢	1)>H*"Ï&XÉ%ä'H+x cK*Ë-ê Ö!q-æ“)¿>ý=ÁzY?K£Õ	h	Â	0¨âãUG
!"Ao!ÉÊLØûÿ‡¥
:LTÃãä†De; ƒ £ ÿ ñ!†#©#²#Z$ÿ%.PK˜!#�
µyjq$-&À&ÿ))» 
 È)g8‘p¼Ü !,)çz®±mí¡¶Ð#Š�³Ü‘	RÞs’w&d½_r&"�&—+Û	e?¢üØF¹X|¾Eóx 	RcÞs%°&K*à*Ë-ë,5!!´,Àñ#ê,Õ‡¥L£ †#_y
SÆ¡O	†	�™Ü®uÏ¿,™÷n[ëü?Ñ^`„ØÜh u ö!?"™&"+w+h-/(,ˆ,_%Y?KÕh	Â	GoØÿ‡¥L£ †#×L!å$ñ+Ù-s,[ 8Ýç¤“ì5	Ó 8ù"ÑQïó]r1œ ~¹ÜlyÅäz†úO X « !!$"Ž$«$%n%“%Ã'J)?-Ó-ç-ë-Õ¨L‡¥:LTÃ†; ƒ £ ÿ †#< [ þ£’_%Ü,¿ü sßô”�M›¶Ø=\b8t=!}!¿!è!_"à'ë'A(M(M+^+aÊš†+H ›(–M&e*#AóI"#Š$�*ã†ÿ ×Œ!T(g(+ã? gïÆâ%!k#u#€#§%9&u)
Æ¡,ö!Gâ«½T	•
cŽæN�n'£è¢	'Ét1)†+Pš�”ý(È÷&È'C3	]½¼$ 4] !k' 	0
^^šÀn-z6_¦Q""áî<†¬NQÏzÐå$™VÜ™&�(w+h-Ì_-h÷æS	£	&‘ybú'sGP˜�(ùºä¤¬!y$’Ä#›$H&Î&0'’'å'/(2),ˆ,¦,(.Á®  ²&Õ&X:!8Ü!6ÞñÿKf†Z ï ÿ v!­$³&¨'U+'-é-@»Ðu¨#W)Ùºk ³#A
Ñ
KÆ6ÞÿKv!­$é-(>XH"*"É%Ï&ä'H+2�þ+¬ µá*ü–)z+%B*7$¥+]–·êW
æºÏ!º*^-ƒ!ò 
Þ!þ!è"u*æ
ô”ÏM›¶=\t=!à'A(M+tàF•‘œ·>c9"`"–'ì'N(*_+zÅªêö�¼,	
0óð""nÊeÚâå:µä&D�ë¢¼ V!ñ!Z$z%ó% &.ë -6¬"!×!,µ,ÔÚÀq-æ“ñ#)ê,Od™œä$	2	9	�
58\¤¿Ð×à»ý	AM^Þûe‰¥½.dòBíU\\ ¨ !u!Ý"¯$ %%µ&ö&ù&Ç')}*à,µ-þ-­©³¿	ß²êè°Æík‰®¯ÇÂlî=™šìúÑÒe­ç'•ÄáÀä ó ö#)U)f)D*¬,Õ-		D	žãäqêhªàfÿ Ú&’)ñ*æ,	-Ù�wÖi¦ïš˜¶*§+Ã,Ì,‚µ4º;ÁÇG(*)˜+­©¿	è°ÆÂ=e'•áó f)D*Od™œä$	5AMÞû‰¥.díUu!Ý"ö&ù&Ç'}*à,2	9	�
8\¤¿Ð×à»ý	^e½òB\\ ¨ !¯$ %%µ&)µ-þ-ûÆý	NO™ás‰ƒµ* )|)›*5c…GÂg¦[ÆBöí	šÍëÉJŒ³‚Z€= ô#E':.Â
§!ÉZSéZ· þ—Od™œä$	2	9	�
58\¤¿Ð×ûñà»ý	AM^Þûe‰¥QT?v…¤™´áüh�¶½à.d…åòøûB…èíUr¶\L \ ¨ !!!J!u!Ý"®#¯$ %%%‹%&&µ&ö&ù&Ç')b*}*Ü*Á+à,M-µ-þ-zÅªêö�¼		,	D	
0žãäóð""nÊeqÚâå:µêhªäà&Df�ëÿ¢ ¼ V!ñ!Z$z%ó% &Ú&’)ñ*æ,	-.?ÃÝí
+ía·¡Á	ü"·%Ó)‹+P-œ-Üƒ
cå¥*-‡-ë žh¡šì–Ôé/øž!Ò!ò&ÿ&³*”ñ
¶É×,ŒÉÝp#—$t'
)€)«)b+$.>.„©	Jb¥Z/�Éä-ø-üÇþ	î
aDPâöŠ)¶ÂÈ(})œ*yœ	¦ü•ÞB1!e"r&(±( ¬…*3¬€7ì!»#Í*b-¬î½�¨¥M	ù
¯%Å“ Ê ›!P±p‘àÜ V (vÓü(Š°µ	&
°¨�Ðˆ<Äž¼KhŽ9Å-Ãà9%€%V'�(’*Ê,í,½- y¬œ	m
…¦�ü*3•¬€Þ7B1!�!ì!e"»#r&(±(Í*w,b-‰œ))'
ò
—·ÊR�Ø-ÊN'vu"(¢()f*?.® #œAóg Ig•ß÷x "#Š$÷$ñ&þ&�*ÐorÂ57€ìÅ%(K.B£Ð+÷ÃY¤4 !õ*#-ð s«¡žm<ÕÆ‡ ÷Y þ R!_#�$O÷
Ë6¬È È$)-3-Ó-d×·òv¿ãJ	zÍ•euÉ¯ ˜¦À 8!P"º$û$F%Ò&×(ÏúºÆÛê‘€ÙÜZ~¥/\ÎÑÄ%Þ(å)+.8.™ ÿ z×¥�´ýK
¦©º„ñÛ2–2!;!ë!f"Â"º#Ï%&~'(‹(I*T*Ì*Ö,S- ñ	~_XÁi&wsß0‹¬Ñ ß ö ú )!E&{'?*‰ +Ú¸Ç—
çwáT£AYÂúÞ¢!Q'R)¶+Å-+ bk_s	¹�ýx›]m™:ÆN"W"ê"Ä&'w'’(Ý)*°*l+ð,.'.s¼ÁÄà�	wÉ,ÍÐ{é'¢Ø‹M!æ$D(7+…+ò+Ú-J	˜8!Ò&d×z•¯ P"û$×(b¹�x›m™:ÆN"Ý)°*ð,'.·òv¿ãÍeuÉ¦À º$F%· þ—ûñQT?v…¤™´áüh�¶à…åøû…èr¶L !!J!®#%‹%&&b*Ü*Á+M-® #‰œœ)A)'
ò
—·ÊR�Øóg -ÊINg•'vß÷x "u"#Š$÷$ñ&þ&(¢()f*�*?.Ø®õ´’Ë»"¸$`(.Ú‰‘"Æ(õ)ò æ`ÆÛ+Má‚ ž* è`
Õ"PVÊoœâ~ç>z×ýVXx‡Èê{›åÇ  !!Å$Ç$�%Ò')	+U,¹,»,"-¸ ŒhüÔò Ôùñ!Uð@tw†¥¬Ç¢µýŸÒá,nãæ=`Öùü*†Çé	ˆš¡ÊäøM Z ÿ !&!K!S!`#l#v#�#¯#)$�$ê$Œ%¨%'&:&³&¨')v)c*+U+Â+T,€-š-þ!O—ß }Ç
÷
 )QË™áäh�¶…–6yˆŽ¬²Úr¶@ È ñ !!È$Ò$%%1%!'±'5*Ü*%,-)-3-M-s-Ó-u y^&—¸ëˆX
A.�êðç«»ìZ!Ð!»*_-Ø 7Ç®ó`6æ§¢ëy	œ
7L[cºß6BCO’-l�“ LRÜiØÇÍf�ñA • w!÷!#"ß"Y#¾#$n$®$$%&`&Ž&�'˜)ü);*â,õ,ê-G.¡çéb»'	0	<	À
¢å÷{£#O�ÉpùXt}²?ÊWƒÉëXz|œæÆ …$Æ$â$%&T&¸&f'Ó'\)¹)
+V,º,!-£-¸-Ö o˜(°Uˆçíþ½Î}"["„"&#W#ä#N'K(š)y ý t] àõ·“	ê	F
F–Y•‘ÐNiœ§·ÙW>]dc¬ç&9u"À>!~!À!é!`"–'á'ì'ô'B(N(·(**L*N+_+ƒ+Ì-xÈ™~³	ß³ëØçîªí;lŠ¯ÇÔlîšS„í›ûÛßÒ­èÄÏçý)tÀä !!I!§#­#¶#á#ö#¿$m%x%Š%<')V)a*¬,Ö-<.		E	�
žäh¶59zqk’êöq½Ýcir«%�ág  !E$.&Á&Û&™'-)O)’) *ò*ç,	-' = \ ž šÖ	£
¼
,ïú­>ÜS³ÿ;!Õ8ˆ¦ M¤×“Ìòq¤ “"L#‡#$`%0(*%*s*—* ,‰,Ý,Ø ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¢ëï	8	P	y	Ÿ	

œ
7L[Ößcœª³ºëÓØ7ßçî?mªí;lzŠ¯ÇÔ 6BváùCO]‡à’½ÿl-Pdl�“îöoŒš§³ßäø SìLR\„Üíi›Øû+:FLj‘ÇÍÛßfx‡�ŸÒñk­ÀèA_ÄÏãçý)t¸½ý…À i n • § ä !!!I!w!„!¦!ï!÷!ÿ!"#"ß"S#Y#Š#§#­#¶#¾#Õ#á#ö#$C$X$n$®$¿$%$%m%x%Š%¤%&`&Ž&“&¬&û&<'G'r'�'ú()/)I)M)V)˜)ò)ü);*a*¬,â,õ,->-B-´-Ö-ê-<.G. ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAP�š¢Ö—™Ü	Ø	ç	
U
h
€
£
¼
ý
,Š½%†ï?ŽÉúŒ­>ÜŽSl³ÿ;zÀÂ!Õ¶×8ˆ¦ M¤×“²Ìò>Qq‚›³¤ “"«"ã"L#‡#Ÿ#$$=$L$`% %é%]&'0(x(z(|(Ì(ï)*%*s*y*†*—*Ù*+í+ ,,,‰,–,Ý,J-n-p-À)ä
?þèÝ(?>ÂXœÞÐÐš Í Ú (¾)3+s,-. " Z ¾ >˜Ë<,Ü	B
…
º
à
fÒÙG-�âZŠºYe@£Ð=›8TgˆýL	}¿F¦ÇôDðÝ²"Ü" #¡#í#±$š&Â')k),*„*x+ß,i- .³ Xm�ÂÏè†¦—ž¸áê)^kt{	É	Ñ	ä	1
b
ª
‡u…Æ_´Èj_E¯,¯M ª!#’#ü# $1$|$X(Š)‰*.x3h™Ø	¡	

KŒ�ëW³¥²µÖ"ð27bÞ÷ûó&Å¨¸ÍôQÿ—§“0 ç !0!N!"d"²#¸#ð$&y)G*Ô,Ø-ôù$p®±»®¸>¥‘W	§	º	à	
N
mWÆÔCfKÀE®;¤ýX‚é¯Ùí}„¡oÕ¶Í"¥#«#Ð#Ó#ß#Ï$Ò%'¦(÷(ª,Î )Kt’À™ª¶Lö	6°ÊóØ9b`!�!"z$µ$!(U(Z(h(�(ˆ)¯)+�,E-
.p Ø 7¯Ç®ó`©6æ€§H˜ÉžÀ)’¢×ëy	»	Õ	
?
œ
ä
/7L[?coºJêü²Õßò^·ÿH\p6B¥þ6CO‘Ùè’°€Ýò-l�“Àt Ä(LR~ÐÜá
?iØ%2>^ÂÇÍõCXfr�ñœÞAn–¦ÐÖêÐ  • š » Í Ú õ \!w!÷!#"ß"Y#¾#$n$¢$®$$%Ó%&4&`&l&&Ž&'z'�'(I(«(˜)¾)ü);*3+n,s,“,Ó,â,õ,ê--.G.Û Îçù‚ò\‡Vä®Õ¤ 2b§ÓÃ%g+  9Á     +  +‚        +‚s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘9>Åì³ß`?A+Ž;ã‚tè6@[ô†Dý"þ‚ÈSÐMp‡èÆ"X4ÈƒÿÛ~Þøžáƒ½4Ûí7×\çëÕw ~lãxO�þ3Ïo~æ-Qþ?à\ŽMÐB"±Ðsyãø¸íÑü#�M»8#"2ûc=ß^{ë³ø6·ÛÝÔ­­Ðyµ�#ø` ÐP†/m6ðáR4T¶ýÿO¡ÞøÑ8#± C�Ñ²#´ôÓ(b—¨bëï]×]õ;5¿µÖáêÙeòŸUKáþ×ìmI½v<5ç¾2Mr4Mï~ö+¯	#ç¡z¸Mí½!ò ×íRØ Cçô>5
¥à~~þ«‡ßO„ýNŽXçßPwgCwë»¸ÿ>þá9ï¯ƒÑ_ÐC�¸r¡;¬gÿÑ	L¶`v¶×àßêˆŽ>à'ÿO×!Ø8Ò4ƒÝá�ˆaÔŽ4.‡ö„/„ôú÷P‡Ñ>8x¡¤M×ÕùÄ�÷]2 H;à>¶nãA?w6ÿÁ„¯ºÝô‚>6/mƒèãŽ8ïŽ9¢u&SE?R}ÎlDæ5Ò™êÛ÷4ãé×H¯ü_�*	GûàO¨ CÜ> ¸A8¾ âc…/pýŽE?¶/…a=øMÄ]²×ë€O‰ý�âx-·ž(æ~;^®1AC„=Žý>ü=ü@C,y”]½ûEf/4H:ïO@ˆùˆ„>.÷®µaï®á5�Ô`pÿ�;À~:Þ»ÓÔ“ôƒëìëÔZ6÷Àr3%Èâ‡ÖbQ ¬@vØX{×�¢Ôcóãâ�ƒý6ê"çp­¸/˜6ûî®Þ€áoçø6ø!tÔ®ex!A�ŸVÓãj?ÕftÛcCã€úýýÑýúôÑ¸ï¯­ÐýDDÀyŸ[�M4S4ÃM4Ò�;’~Ž15 fÏÓú8Óõ×›Jã„øÆoLÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘Ï}�DÃãóØ±#Í·Ã…Ã JÄà€Ã@ßýMÍ‡×Q…}PÏáúÓþ~8OrpëŸzÃ~Óqþ¾7=µ×9ß]üÛIÄ0Èãr­9óœCÃÌ†Ãµ 7Ã¯ñL†ë|uo4×=òß�ÿ`1—#‚N³ó~´øÌpÃžtë �ÓÝ�ëQ3ÛßôÛãEÀö+>¼ó A8Ý5ß€Û IôÜúÔöÏ¬ôoÌí,½k� pß<Ã½ðnÌ@Ñ.¹v0‡ Aü?˜|IÔýÂ3ì÷órÿ@òs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øV×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           •  —  ñ  	   	  	  x  ‡  Ž  �  +�  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *Ó<?xml version="1.0"?><Features nextValidID="23"><Feature recentID="22" name="CSF1R" directionality="1" translationMW="107986.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2317-5235" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="21" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2311-2320" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7704" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="7321" maxFusedRunOn="7321" visible="0" detectionMode="exactProteinMatch"><Segment range="7705-7716" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="8537-8553" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="8606-8627" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="8561-8567" color="#ffffff" type="standard"/><Segment range="8568-8585" color="#ffffff" type="standard"/><Segment name="-35" range="8586-8591" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="6630" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="7233" maxFusedRunOn="7233" detectionMode="exactProteinMatch"><Segment range="6580-6633" color="#cc99b2" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10535-10639" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8200-8321" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8340-8475" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5297-5508" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7895-8128" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5521-5789" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7234-7821" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="8915-9503" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="6634-7233" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="7233" maxFusedRunOn="7233"><Segment range="5848-6510" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10465" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9674-10465" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10466-10534" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>b64490df-681d-4c2f-a3de-086749b86fba</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:7:56">2022.3.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   «<StrandColors><TopStrand><ColorRange range="0..11137" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..11137" colors="black"/></BottomStrand></StrandColors>  3p     R            s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘9>Åì²¤[þ1›Ó0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`DÇ0øüölHómðßápÈ±8 0Á7ÿS@óaõÔaDßT3ø~´ÿŸŽÜ†œ:çÞ°ßŸôÃœEÿ¯�ÏmuÃw×6ÄRq28Ü„ëN|çðó!°Ç­BðëüAÓ!ºßFÛÍ5Ï|�7ãØeÈà€Ó¬üß­>30ç�:È t÷czÔLö÷ý6øÑpýŠÏ¯<ÈN7MwÄà6È}7>µý³ë=ó;K/ZãÈ7Ïðï|³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           •  —  ñ  	   	
  	  	  	$  	+  	-     !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ']<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4789" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4406" maxFusedRunOn="4406" visible="0" detectionMode="exactProteinMatch"><Segment range="4790-4801" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5622-5638" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5691-5712" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5646-5652" color="#ffffff" type="standard"/><Segment range="5653-5670" color="#ffffff" type="standard"/><Segment name="-35" range="5671-5676" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3715" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4318" maxFusedRunOn="4318" detectionMode="exactProteinMatch"><Segment range="3665-3718" color="#cc99b2" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7620-7724" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5285-5406" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5425-5560" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2382-2593" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4980-5213" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2606-2874" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4319-4906" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6000-6588" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="2" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3719-4318" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4318" maxFusedRunOn="4318"><Segment range="2933-3595" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7550" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6759-7550" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7551-7619" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>b64490df-681d-4c2f-a3de-086749b86fba</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:2:54">2022.3.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..8222" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8222" colors="black"/></BottomStrand></StrandColors>  8ý7zXZ  æÖ´F !   t/å£áÄ|ø] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnãýJ„<Ú§^ó˜÷rÆžÖ�çä™…Td²¢Äåºš…À")fMÿÍÆdR‚[´Ø´S_*¾lº¨"Mu·×²}Àkd”¹˜¾}§´�+'ü¶wSÎ³¥ïï>o/Õ¬‡}qsÖ6øh<•ÜË"Ä¥
BY¯üç›ð¶Ù;Äã°²Á¿Ž½ßÑÅ¬°Dq0·=9«`C¶Y�‹Omòƒ|Ì15q”\B² ‡q–bï¡Èá=áõSgqÚÝ…2¶Š~²	‰Ä±¸m¯Ý)Áõ™’±½Ø–ÊÝžùþ€)rûS•�“0è¸=Uô*óz}¬ëŒÁ#ÏûåC¶7WTvþèW²Å!)Ü7ÿµY¾J÷Ã'ó2Óôb¯œÔíDñÎÿ{šmÜDŒ}Âµ15ô]Ò…0á,ñt�µS«A¦4í½?Ô÷äô.p�ö‹Yìôºé0�Ji® <¶®7’C£Ó‘¤\(Êuê`àð=Ng…OøkLy‰@
½LÏ7¯¥Ú¢4èO	ÌcTøzâ˜Æ�âcö´äÓóT“ #Y†0_­(Ž]o…ü¯ß1fË¨ŸÞc·FÖ…)úXH�\Hí.º/*É7	7˜S}ÆÁÄzš*Ž(6s!ÈšS{—˜­[Ž3ZÒ*Õ:ƒ,Í±yeæY‚±�p;7~=œ×€cš¤Øx¨ú‰L¬ótH´óOÅU–”S±ž–$0ËPD8d 3,$(ëUfë7�ïTÓQP•"�’Ô¾0Š+9·T Òü-ê/÷?-ù*ugü–ÛVÑÿ•?5˜S”²ã^¬ºº ®hÿsvL'«Jé¶PÅï¨ù«¢G§ý¿I¶°JÜ;_T³¿µ|þ/À�YÂª_'0Î•r—¸ÆiL ©ôëÑÑÚàƒª@¾f¾p�PŠ|†$ê¶=1é‘€1ú‡çÏ·÷R[»æµ¢{Îônæ²Ê �¾îðJ=TÌÆOñÚ²ïb0^ÑÍ²8}ùÝ±ÁŸ`ê4ãvê¤¸Šf\5/€ÚAÑ� £0Çô­JÝÖûþ9¥%sø/ƒŒ¿zÒ�<_¦•#ž9
�ü˜
a®+¬ä�œOŠ¤î¦Ê%‰�žò7~×W¬wCó“h‡‘Ýo8{¥Pn=Ï:àKhËû•N×jAKÂþF i‘A‹b-å]$§rJl<<¹Ž„åtJ¼d»oâ¶}¿W¦Ë™øvÈ	à@}Î4�p0[�-h�;Ð§¶‚*^8ÛÖÚ^'VG4Xa47d4'>•EHtbK”Ð]¤’v,§ã
“ÿèk®HDÅt!”çLðM^¹_ÙAæõpPn6Øñ)Ð‚¹´™¼}‘e~÷{÷ÕO²ÌªIqé©ùd
ªÃ"i[T3ŽnRsX©Û‡¹¬9ˆß#ßrG)Éú$Áîû’îy/?6AÁ“ŽÞìÁ5ÄÏÁðxõ¡ŠúV±wfË;Ë­«éëÈ]™ƒÁ}ˆ$­Ö¸`�½w!½9ã°â×úÐ�æ¸'�á»ö¦zvúôyÍÀ¢`K{#ìÙxÉq0ÎQõ�U�ö3Œ_q"™–>jÔc½SdÐ3¾i Ü*'ó¡S ÿYøÀ�±Ž*J‚|ÖÊ$uHÙ¸Ð'voñ=NþCºQW§§Ü¥;³|Léf}ßà,®í%ÕÂ‡ä
d%0õÅ&ŸZ$Önw5ºµ?ó?£ØXfLo@­ÄÆèO=O{ÞEwR†A6ItFÍ¡@·ž*TÚ\ÂÐ�*sñî$âK –óÚ�Þ�W³”�v›­=¥øhÇ«øIjn’Îâ=‹i}òÁù.§]×}à§Y¿ÌÏuÎ >Íå±îm–£xòhR¥¥üa0Ïâ“™Š­Ë	iøñôBÐ�õ”ìT–o¿¢|B¿Üï‰°ž5ÃLI¢K¦<
‘‚€OZ¤Ÿ™HâøÜXÉßþ�.ú‡Îÿ¥ÕÙS8%YñH=BH3°O“zÞÞlÒ¿Ð^òI.äÍ%@G¡C4swØÊšF388L×“á`jkAvSðÞïò™Vn™Ž'¾ðM0¢¤\V¢G›�¤¹6ÑÌé‹l
‰Je¹
Fc_|fûÚ@š§ôñhšÌÚÀø�Žá­ÜY£@·Ád†þd¨Â«1,2Ï#è�±­×HÀ‹hˆš‹m×÷ o|†\ÔŽÒXÏÜÂb¶ÇUÇD³­Æ‘Á)ÝÉæ)'tó9×Á&Ü¸ƒ]m{õ77À‘ùÒýGn< hVÏ9õ7Åþ¦(YNþ0Å„NÞÎ@óš¨¯‹?ò?*ó*Hš‚|èC/\Î.®Ìš“�ò�.»OPP�€‹Ò"¹&¬^DvÔñY“ÿK:ŽEá’àCâ(âR)²´8C�Z fa·œ²·ª)åâ\¶ÙÞP—±ë(ïgÞÜ•÷Í±ŒKz£u&ÆF¤S„îÒÎâÝ¾ŸÕbž·áÝ–ÚƒX`îÎÆ¡úÜQPóïneº}†^@Ç¥¿�¥{ûíÅmù‡Îèå¹gl—Ï•ÕŸÒc¡h°ñz%p‹d™êïgL»¼ å­;EP÷ª�\Ö„«-Jn¾ŒÒ[,†Ï£°›b€J%Qª_˜Ì üd‰‘BŸàau>°`€Ö¥]û8OJË¤Æn¿‚,|ä&Q26uø–%˜|´÷�ˆ3F°ºôLœ�{ÿ1âGÐó–3á²àdÆ‡hß”¨¶ðfÎlñ3½ÖÁØÅpD&æMR^ž ÈP�Z	$=ÏÄ¤·-A\�}ÄÂ˜jvó òŠe2õIq‚mG¥ÚÞØJÜo~d¼òÈ:6	=ò‡˜'/ÌÎR>™Ñk{ª(0dê•áúëž5Äõvžése¶%¾4Pû‹QWoå™ ì¶¬/@Q×ZÀqªG‹[ö6Ûr5z,Zö_gt£ƒ#½fl’’†€(:s‰\C¶®·Ät=x�“é+¤HUãr&ŽÝç·‡Â3³��©Þ.ŽÎÏD<Z…2fŸ…¶Až,®M®'æŽSÀæ´ùÍC¥o=eÄŽÌ ’R‘�l› Â³èwHE”Gt¤,÷"ë2xµdü�„6Fn¬ÉGlO7Ä½Ìê�Ni=ì#ÛÕk§
_ÃP½4ì®DÄ)à8eãnT$ˆÐÛ>îr»#³vpdß©ÒûQ6”V"¯ >NÁõº¤q‚ç—¼_\f¨�Fq.

^–þ­'‚Œ4i	�:]‰»£-<0~º&Š�ÇsYTü|o`¢ *[6„‹ÇŸ6¹¹sPuY|`ì™©Õj›çËq;ûÃ‡9éN�“ïO.©Ž¡[Øµ7�áæ´·áYYæIP0'¼ßZÊ.îkCØ�rß¡�hu ö¼Ò­¾Œ“Æjèh#ØšJg&KÃŸ˜:LTéßZ ÔÙ
Ó¬¬6µ‚.P'%ñFÃyrÇ+‹™¢ë¸Ú2}Z£+¦7å:¨c‡œç€Júž1Ø]k&ÿ³£÷L”ö§4oyÐßbÊt Çå"
ûP3Euž£ñ?Š¡ª$Ýc‚*L"»ÎúT�Þ°D@»’MfÃ�ôó­[ò5»ÓC�~Jã„Òºüä«Ž’µßš�NxkÙ9ž± sA•µœ]4h^ÒlwWÄ‰FßyŠy–=(½4f"h‰BæšíI™ÙnºYË)þø·– Úu2„xzP@Ù¨u’p»A)Zƒ§¬²2Ýâà^‘ÕŸŽk��ð<£–ER€dÎÏòÙ/åö€„£¤Ñd¶šû‰¹ÅLOŸâ¬ Œºm\%q“òJå4_?Ÿ}X–Ð�]Ùq5xñ›ÇüË$Q P£ážÌÓÏGVÑåÓÔu-ì9ì¶N8å”(XÑ¯œìA²m—iúï?¶¼##ÿVÀqº^œVFÿÉþœ´ú»­5Vðã–¸îª1Ë)>®¼×‰Nji…XÌT!±»éÿâñ`îÏR•5¹èÙ|>eŒðb„¯Å=¥A6xY–�Mš™Ü…Õ�Ÿ�ÇõÞ">�ï„c�Žó(•3À“ÛË¾O0Ï‰OCO4Ìë–ûÍÍ€vÅ(-åÍ“P4Ëôp;ÃHD¥$O´Äš3›
üRÙ{��*^Œ™Ü3VzÂ °«u Ñ¸hl0$N±ìè˜;AŽË�¹yz_
�xõ�äzº(éâ²gÎ�vtäò;…*Á§m¿À¬¦»WÿÁìn?Œª]Á\;ÊUãKu¢”a~±Ðmæ˜~�Oà97´Y‚“ø*âÙX`-€�¹¡¢?°ó¿Ú·¥Ç£L\³á7ýoˆM¼vÀ37Rð�fóR¼&P¶'¦q:gØ?Ç•«'á¸E,ga½RÝéº
©Œ".…}Wä�W¨˜iU¾ø“¾Õ•Êbê­c×+îZÔ �7éÄÇ‚¨#l.F°ßtUé¶4&Ø¼ÈÂ…ó¤'=Žð¾W)4Ü•�¶i‚�7ƒÝ=9ÈšÈÎ™$°à?Ùõ&“YÉ¡¸F±3{js¶}³¯çûðÇ ¤»‰7<gâ7BÏ*ÛU%Ž¾BQ‘S^<²u _4;³B1…lú(¤Ì˜ˆw.w°þO7t‹—c/á~ÝfÝc‰üÛp"¤n^žÂ`6jØøJúzWE*M¤RŒf÷©ú­›é¸-•Ø^‘‹*™nÂm!GÏ~Òê�*ïäJ™†š®%[›N‚jÝïIÕr¥ónçÇhÁÛ¹®"×�æ¨€¤ádÍ! ‚úÔuÇ‹üFÌ&rÉ56RÈ²s
\­È¤4øëZ"y LM˜Æ9Âœs=WâÍìlj¨��J»ÍQZ^‘Ø÷¨mÕQÀqpyŠŽwª÷ÀøpyÛ´WÇž¯'c�sTtÝÉXÒÒŸ)½>õÌÚêP1n�
M­ÂXÁÛ*i4ã]à£±�KB¶NHHÉì€TéhJJÆ±ÆÑæ]å�aÒ))­¶šæxÈÏt>%ÆÜoÙI�¼ÅéÒÒ)Þ�÷J$U”‚yTg+ü¹[Å—sbö¼,Âµ%
íVeú›GÁ±À—ïNu.Åí®$ÇÅ~ïí‡§ èÍ—¸Ë®½cÑ9—Z[ö—aQ®0ú)vü‰°øEa˜/Ò æàìøýÛ*�”ye¤Tâð«Û¦Ì+åæéO<åÓA¹(ƒÛ¼IòžQáÿú«�(çx°veÙîÄåï²ºÎ¹â�}Ê·úLŠMuÁ$²Ÿàó[œD)'ã90ÇÂŽk-¦#zJ£ç|�ûïß�[{.¾q„¥XD É*ÍA‡�ÿb’kÎ%-ï,fg,˜�6Ð;†]#÷”èüBÀÂÈ}ÅDè!YâQs»«<æ Ü!›^N]9m´µHÁÔjjîHÃúÐü±€"’+ð.Í–œ ÒAŸÃþE¾�#Ò×ù›Ïã-¯ lõUÛS-¸³�/§£öÒNå;.L”W�ÅþñVR¸5—j­{œÈ�^hô'â3‘Ò"�ï“qð'rß¦êÚ¤1@¡F¼²E3C‡„?—Êûƒ>bÐJ»’3Í}¾žêœêŠ#§SÕÈ�"ã§,®Ò�°¬t$\³÷@Ü‘(›¥¡¯K=i_}šŒjÊÇ�Ø+ÿaYúºcW=(89eôßKaÜ– ƒÍï´2?—$+ƒì   ÍöÑl¶ƒ¦d ”"ýˆ iîÈ*±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  6¯<?xml version="1.0"?><Features nextValidID="23"><Feature recentID="0" name="EGFR" directionality="1" translationMW="134277.91" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2388" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment name="signal sequence" range="2317-2388" color="#993366" type="standard" translated="1"/><Segment name="extracellular domain" range="2389-4251" color="#993366" type="standard" translated="1"/><Segment name="transmembrane region" range="4252-4320" color="#cc99b2" type="standard" translated="1"/><Segment name="cytoplasmic domain" range="4321-5949" color="#993366" type="standard" translated="1"/><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;precursor of human epidermal growth factor receptor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MRPSGTAGAALLALLAALCPASRA,LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS,IATGMVGALLLLLVVALGIGLFM,RRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA*"/></Q></Feature><Feature recentID="1" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2311-2316" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="2" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8418" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="8035" maxFusedRunOn="8035" visible="0" detectionMode="exactProteinMatch"><Segment range="8419-8430" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="9251-9267" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="9320-9341" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="9275-9281" color="#ffffff" type="standard"/><Segment range="9282-9299" color="#ffffff" type="standard"/><Segment name="-35" range="9300-9305" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="7344" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="7947" maxFusedRunOn="7947" detectionMode="exactProteinMatch"><Segment range="7294-7347" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EGRGSLLTCGDVEENPGP"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11249-11353" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8914-9035" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9054-9189" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6011-6222" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8609-8842" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6235-6503" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7948-8535" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9629-10217" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="7348-7947" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="21" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="7947" maxFusedRunOn="7947"><Segment range="6562-7224" color="#05fd14" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PAMEIECRITGTLNGVEFELVGGGEGTPKQGRMTNKMKSTKGALTFSPYLLSHVMGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVVGTGFPEDSVIFTDKIIRSNATVEHLHPMGDNVLVGSFARTFSLRDGGYYSFVVDSHMHFKSAIHPSILQNGGPMFAFRRVEELHSNTELGIVEYQHAFKTPIAFA"/></Q></Feature><Feature recentID="22" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="11179" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="10388-11179" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="11180-11248" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ª<Notes>
<UUID>0fd680a4-bc40-4f5d-8fda-ede81c599627</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-CMV-EGFR(human)-CopGFP-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="7:15:51">2025.9.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             g<StrandColors><TopStrand><ColorRange range="0..2309" colors="black"/><ColorRange range="2310..2315" colors="green"/><ColorRange range="2316..11851" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2309" colors="black"/><ColorRange range="2310..2315" colors="green"/><ColorRange range="2316..11851" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
